Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5.

ABSTRACT:

Background

Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. Approximately 44 human genes have been reported to be imprinted. A majority of them are clustered, including some on chromosome segment 11p15.5. We report here the imprinting status of the SLC22A1LS gene from the human chromosome segment 11p15.5

Results

In order to test for allele specific expression patterns, PCR primer sets from the SLC22A1LS gene were used to look for heterozygosity in DNA samples from 17 spontaneous abortuses using PCR-SSCP and DNA sequence analyses. cDNA samples from different tissues of spontaneous abortuses showing heterozygosity were sub

SUBMITTER: Bajaj V 

PROVIDER: S-EPMC425576 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature