Characterization of human chromosomal material exchange with regard to the chromosome translocations using next-generation sequencing data.

ABSTRACT: As an important subtype of structural variations, chromosomal translocation is associated with various diseases, especially cancers, by disrupting gene structures and functions. Traditional methods for identifying translocations are time consuming and have limited resolutions. Recently, a few studies have employed next-generation sequencing (NGS) technology for characterizing chromosomal translocations on human genome, obtaining high-throughput results with high resolutions. However, these studies are mainly focused on mechanism-specific or site-specific translocation mapping. In this study, we conducted a comprehensive genome-wide analysis on the characterization of human chromosomal material exchange with regard to the chromosome translocations. Using NGS data of 1,481 subjects from the

SUBMITTER: Xu C 

PROVIDER: S-EPMC4255766 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature