Structural and functional profiling of environmental ligands for estrogen receptors.

ABSTRACT:

Background

Individuals are exposed daily to environmental pollutants that may act as endocrine-disrupting chemicals (EDCs), causing a range of developmental, reproductive, metabolic, or neoplastic diseases. With their mostly hydrophobic pocket that serves as a docking site for endogenous and exogenous ligands, nuclear receptors (NRs) can be primary targets of small molecule environmental contaminants. However, most of these compounds are chemically unrelated to natural hormones, so their binding modes and associated hormonal activities are hardly predictable.

Objectives

We conducted a correlative analysis of structural and functional data to gain insight into the mechanisms by which 12 members of representative families of pollutants bind to and activate the estrogen recepto

SUBMITTER: Delfosse V 

PROVIDER: S-EPMC4256047 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature