Dissecting dynamic genetic variation that controls temporal gene response in yeast.

ABSTRACT: Inter-individual variation in regulatory circuits controlling gene expression is a powerful source of functional information. The study of associations among genetic variants and gene expression provides important insights about cell circuitry but cannot specify whether and when potential variants dynamically alter their genetic effect during the course of response. Here we develop a computational procedure that captures temporal changes in genetic effects, and apply it to analyze transcription during inhibition of the TOR signaling pathway in segregating yeast cells. We found a high-order coordination of gene modules: sets of genes co-associated with the same genetic variant and sharing a common temporal genetic effect pattern. The temporal genetic effects of some modules represented a si

SUBMITTER: Brodt A 

PROVIDER: S-EPMC4256076 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature