Leishmania donovani infection enhances lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterol.

ABSTRACT:

Background

The protozoan parasite Leishmania donovani (LD) reduces cellular cholesterol of the host possibly for its own benefit. Cholesterol is mostly present in the specialized compartment of the plasma membrane. The relation between mobility of membrane proteins and cholesterol depletion from membrane continues to be an important issue. The notion that leishmania infection alters the mobility of membrane proteins stems from our previous study where we showed that the distance between subunits of IFNγ receptor (R1 and R2) on the cell surface of LD infected cell is increased, but is restored to normal by liposomal cholesterol treatment.

Methodology/principal findings

We determined the lateral mobility of a membrane protein in normal, LD infected and liposome treated LD infe

SUBMITTER: Ghosh M 

PROVIDER: S-EPMC4256160 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature