Global proteome analysis identifies active immunoproteasome subunits in human platelets.

ABSTRACT: The discovery of new functions for platelets, particularly in inflammation and immunity, has expanded the role of these anucleate cell fragments beyond their primary hemostatic function. Here, four in-depth human platelet proteomic data sets were generated to explore potential new functions for platelets based on their protein content and this led to the identification of 2559 high confidence proteins. During a more detailed analysis, consistently high expression of the proteasome was discovered, and the composition and function of this complex, whose role in platelets has not been thoroughly investigated, was examined. Data set mining resulted in identification of nearly all members of the 26S proteasome in one or more data sets, except the β5 subunit. However, β5i, a component of the imm

SUBMITTER: Klockenbusch C 

PROVIDER: S-EPMC4256485 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature