Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication.

ABSTRACT: Ovarian cancer ascites is a native medium for cancer cells that allows investigation of their secretome in a natural environment. This medium is of interest as a promising source of potential biomarkers, and also as a medium for cell-cell communication. The aim of this study was to elucidate specific features of the malignant ascites metabolome and proteome. In order to omit components of the systemic response to ascites formation, we compared malignant ascites with cirrhosis ascites. Metabolome analysis revealed 41 components that differed significantly between malignant and cirrhosis ascites. Most of the identified cancer-specific metabolites are known to be important signaling molecules. Proteomic analysis identified 2096 and 1855 proteins in the ovarian cancer and cirrhosis ascites, re

SUBMITTER: Shender VO 

PROVIDER: S-EPMC4256505 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature