A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women.

ABSTRACT:

Aims

Activation of vascular GPER has been linked to vasodepressor effects in animals. However, the significance of GPER regulation on chronic blood pressure control in humans is unknown.

Methods

To examine this question we determined the functional significance of expression of a common missense single nucleotide variant of GPER, P16L in vascular smooth muscle cells, and its association with blood pressure in humans. Further, to validate the importance of carrying GPER P16L in the development of hypertension we assessed allele frequency in a cohort of hard-to-treat hypertensive patients referred to a tertiary care clinic.

Results

Expression of the GPER P16L variant (V) vs. wild type (WT) in rat aortic vascular smooth muscle cells, was associated with a significant dec

SUBMITTER: Feldman RD 

PROVIDER: S-EPMC4256633 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature