Genome wide in silico analysis of Plasmodium falciparum phosphatome.

ABSTRACT:

Background

Eukaryotic cellular machineries are intricately regulated by several molecular mechanisms involving transcriptional control, post-translational control and post-translational modifications of proteins (PTMs). Reversible protein phosphorylation/dephosphorylation process, which involves kinases as well as phosphatases, represents an important regulatory mechanism for diverse pathways and systems in all organisms including human malaria parasite, Plasmodium falciparum. Earlier analysis on P. falciparum protein-phosphatome revealed presence of 34 phosphatases in Plasmodium genome. Recently, we re-analysed P. falciparum phosphatome aimed at identifying parasite specific phosphatases.

Results

Plasmodium database (PlasmoDB 9.2) search, combined with PFAM and CDD searches

SUBMITTER: Pandey R 

PROVIDER: S-EPMC4256932 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature