Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

ABSTRACT:

Background

Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associations, and subtypes in PRISm subjects have not been reported.

Methods

Data from current and former smokers enrolled in COPDGene (n = 10,192), an observational, cross-sectional study which recruited subjects aged 45-80 with ≥10 pack years of smoking, were analyzed. To identify epidemiological and radiographic predictors of PRISm, we performed univariate and multivariate analyses comparing PRISm subjects both to control subjects with normal spirometry and to subje

SUBMITTER: Wan ES 

PROVIDER: S-EPMC4256936 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature