The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities.

ABSTRACT: Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of blood supply to the affected area causes significant tissue damage. This is known as ischemia-reperfusion injury (IRI) and is a central pathological mechanism contributing to many common disease states. The medical complications caused by IRI in individuals with cerebrovascular or heart disease are a leading cause of death in developed countries. IRI is also of crucial importance in fields as diverse as solid organ transplantation, acute kidney injury and following major surgery, where post-operative organ dysfunction is a major cause of morbidity and mortality. Given its clinical impact, novel interventions are urgently needed to minimize the effects of IRI, not least to save lives but also

SUBMITTER: McCafferty K 

PROVIDER: S-EPMC4257001 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature