Total synthesis of myceliothermophins C, D, and E.

ABSTRACT: The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2), and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis, which revealed an interesting dimeric structure between its enantiomeric forms.

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC4257465 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature