Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.

ABSTRACT: A seeming paradox of sickle cell disease is that patients do not suffer from a high prevalence of systemic hypertension in spite of endothelial dysfunction, chronic inflammation and vasculopathy. However, some patients do develop systolic hypertension and increased pulse pressure, an increasingly recognized major cardiovascular risk factor in other populations. Hence, we hypothesized that pulse pressure, unlike other blood pressure parameters, is independently associated with markers of hemolytic anemia and cardiovascular risk in sickle cell disease. We analyzed the correlates of pulse pressure in patients (n  =  661) enrolled in a multicenter international sickle cell trial. Markers of hemolysis were analyzed as independent variables and as a previously validated hemolytic index that incl

SUBMITTER: Novelli EM 

PROVIDER: S-EPMC4257593 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature