Associations between vascular health indices and serum total, free and bioavailable 25-hydroxyvitamin D in adolescents.

ABSTRACT:

Objective

The role of vitamin D in cardiovascular health remains debated as results have been inconsistent. Previous studies have not considered the bioavailability of 25-hydroxy vitamin D [25(OH)D]. Objectives of our study were to investigate the association between serum concentrations of total, free and bioavailable 25(OH)D and independent predictors of cardiovascular risk such as flow mediated dilatation (FMD) and augmentation index (AIx).

Design

This cross-sectional study included 47 post-menarchal, adolescent females [31 African American (AA) and 16 European American (EA)].

Methods

AIx was standardized to a heart rate of 75 beats/min (AIx75). Free and bioavailable 25(OH)D concentrations were calculated from standard formulas.

Results and conclusions

Mean

SUBMITTER: Ashraf AP 

PROVIDER: S-EPMC4257727 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature