Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

ABSTRACT:

Background/aims

The present study identified genetic predictors of weight change during behavioral weight loss treatment.

Methods

Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleotide polymorphisms (SNPs) on the Illumina CARe iSelect (IBC) chip (minor allele frequency >5%; n = 31,959) with weight change at year 1 and year 4, and weight regain at year 4, among individuals who lost ≥ 3% at year 1.

Results

Two novel regions of significant chip-wide association with year-

SUBMITTER: McCaffery JM 

PROVIDER: S-EPMC4257841 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature