Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.

ABSTRACT:

Background

Observational studies suggest an inverse association between selenium and risk of prostate cancer. However, randomized controlled trials of selenium supplementation have reported conflicting results. Thus, we examined plasma selenium and selenium-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with non-metastatic disease.

Methods

We measured plasma selenium and genotyped 73 single nucleotide polymorphisms in TXNRD1, TXNRD2, GPX1, GPX3, GPX4, SEP15, SEPP1, SELENBP1, OGG1, and CAT among 568 men with non-metastatic prostate cancer who underwent radical prostatectomy. We examined associations between plasma selenium, genotypes, and risk of high-grade prostate cancer (Gleason grade ≥8 or 7 wit

SUBMITTER: Gerstenberger JP 

PROVIDER: S-EPMC4257852 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature