No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.

ABSTRACT:

Background

Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results.

Methods

To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α = 5E-08.

Results

After accounting for multiple comparisons, there were no statistically significant SNP interactions with total, d

SUBMITTER: Du M 

PROVIDER: S-EPMC4257872 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature