Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.

ABSTRACT:

Background

Melanocytic nevi (moles) and freckles are well known biomarkers of melanoma risk, and they are influenced by similar UV light exposures and genetic susceptibilities to those that increase melanoma risk. Nevertheless, the selective interactions between UV exposures and nevus and freckling genes remain largely undescribed.

Methods

We conducted a longitudinal study from ages 6 through 10 years in 477 Colorado children who had annual information collected for sun exposure, sun protection behaviors, and full body skin exams. MC1R and HERC2/OCA2 rs12913832 were genotyped and linear mixed models were used to identify main and interaction effects.

Results

All measures of sun exposure (chronic, sunburns, and waterside vacations) contributed to total nevus counts, an

SUBMITTER: Baron AE 

PROVIDER: S-EPMC4257874 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature