Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer.

ABSTRACT:

Background

There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques and next-generation sequencing have identified new therapeutic targets in other cancer types, but an HNSCC-specific study has not yet been carried out. We have exploited data from two large-scale cell line projects to clearly describe the mutational and copy number status of HNSCC cell lines and identify candidate drugs with elevated efficacy in HNSCC.

Methods

The genetic landscape of 42 HNSCC cell lines including mutational and copy number data from studies by Garnett et al., and Barretina et al., were analyzed. Data from Garnett et al. was interrogated for

SUBMITTER: Nichols AC 

PROVIDER: S-EPMC4258049 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature