Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

ABSTRACT:

Background

Interleukin-4(IL-4) is a critical inflammatory cytokine and has been involved in pathogenesis of cancer. To date, several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans; however, the results remain controversial. We performed this meta-analysis to find a more conclusive association between this polymorphism and cancer risk.

Methods

Eight eligible case-control studies were identified through searching electronic databases, including 1583 cases and 1638 controls. Odds ratio (OR) and corresponding 95% confidence interval (CI) were used to estimate the strength of the association.

Results

The results of overall analyses indicated that the variant RP2 allele was asso

SUBMITTER: Duan Y 

PROVIDER: S-EPMC4258052 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature