Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors.

ABSTRACT: The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In sensory systems, patterned spontaneous activity before the onset of sensation is thought to influence this process, but this conclusion remains controversial, largely due to the inherent difficulty recording neural activity in early development. Here, we describe genetic and pharmacological manipulations of spontaneous retinal activity, assayed in vivo, that demonstrate a causal link between retinal waves and visual circuit refinement. We also report a decoupling of downstream activity in retinorecipient regions of the developing brain after retinal wave disruption. Significantly, we show that the spatiotemporal characteristics of retina

SUBMITTER: Burbridge TJ 

PROVIDER: S-EPMC4258148 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature