Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.

ABSTRACT:

Aims/hypothesis

T cell protein tyrosine phosphatase (TCPTP, encoded by PTPN2) regulates cytokine-induced pancreatic beta cell apoptosis and may contribute to the pathogenesis of type 1 diabetes. However, the role of TCPTP in pancreatic endocrine function and insulin secretion remains largely unknown.

Methods

To investigate the endocrine role of pancreatic TCPTP we generated mice with pancreas Ptpn2/TCPTP deletion (panc-TCPTP KO).

Results

When fed regular chow, panc-TCPTP KO and control mice exhibited comparable glucose tolerance. However, when challenged with prolonged high fat feeding panc-TCPTP KO mice exhibited impaired glucose tolerance and attenuated glucose-stimulated insulin secretion (GSIS). The defect in GSIS was recapitulated in primary islets ex vivo and af

SUBMITTER: Xi Y 

PROVIDER: S-EPMC4258175 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature