Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.

ABSTRACT:

Purpose

Asparaginase (ASNase) is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia (ALL), but it is also associated with several toxicities.

Experimental design

We recently reported the results of an association study between ASNase pathway genes and event-free survival (EFS) in childhood patients with ALL. The same polymorphisms were interrogated here in relation to allergies, pancreatitis, and thrombotic events following treatment with E. coli ASNase.

Results

Among patients of the discovery group, allergies, and pancreatitis were more frequent in individuals who are homozygous for the triple-repeat allele (3R) of the asparagine synthetase (ASNS) gene, resulting in remarkably higher risk of these toxicities associated with 3R3

SUBMITTER: Ben Tanfous M 

PROVIDER: S-EPMC4258187 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature