Key regulators in prostate cancer identified by co-expression module analysis.

ABSTRACT:

Background

Prostate cancer (PrCa) is the most commonly diagnosed cancer in men in the world. Despite the fact that a large number of its genes have been investigated, its etiology remains poorly understood. Furthermore, most PrCa candidate genes have not been rigorously replicated, and the methods by which they biologically function in PrCa remain largely unknown.

Results

Aiming to identify key players in the complex prostate cancer system, we reconstructed PrCa co-expressed modules within functional gene sets defined by the Gene Ontology (GO) annotation (biological process, GO_BP). We primarily identified 118 GO_BP terms that were well-preserved between two independent gene expression datasets and a consequent 55 conserved co-expression modules within them. Five modules wer

SUBMITTER: Jiang J 

PROVIDER: S-EPMC4258300 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature