Identification of minor histocompatibility antigens based on the 1000 Genomes Project.

ABSTRACT: Minor histocompatibility antigens are highly immunogeneic polymorphic peptides playing crucial roles in the clinical outcome of HLA-identical allogeneic stem cell transplantation. Although the introduction of genome-wide association-based strategies significantly has accelerated the identification of minor histocompatibility antigens over the past years, more efficient, rapid and robust identification techniques are required for a better understanding of the immunobiology of minor histocompatibility antigens and for their optimal clinical application in the treatment of hematologic malignancies. To develop a strategy that can overcome the drawbacks of all earlier strategies, we now integrated our previously developed genetic correlation analysis methodology with the comprehensive genomic d

SUBMITTER: Oostvogels R 

PROVIDER: S-EPMC4258743 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature