URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.

ABSTRACT:

Background

Upregulator of cell proliferation 4 (URG4) has been implicated in the oncogenesis of certain cancers. However, the correlation between URG4 expression and clinicopathological significance in human cancer remains unclear. Therefore, this study investigated its expression and clinicopathological significance in cervical cancer patients.

Methods

URG4 expression was examined using quantitative PCR (qPCR) and western blotting in normal cervical epithelial cells, cervical cancer cells, and eight matched pairs of cervical cancer tissues and adjacent noncancerous tissues from the same patient. In addition, immunohistochemistry (IHC) was used to examine URG4 expression in paraffin-embedded tissues from 167 cervical cancer patients (FIGO stages Ib1-IIa2). Statistical analys

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4259088 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature