Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.

ABSTRACT:

Background

Type I interferons (IFNs), including IFN-alpha (IFNA) and IFN-beta (IFNB), have anti-inflammatory properties and are used to treat patients with autoimmune and inflammatory disorders. However, little is known of the role of IFN-tau (IFNT), a type I IFN produced by ruminant animals for inflammation. Because IFNB has recently been shown to inhibit nucleotide-binding oligomerization domain-like receptor, pyrin domain-containing 3 (NLRP3) inflammasome activation and subsequent secretion of the potent inflammatory cytokine interleukin (IL)-1β, we examined the effects of ruminant IFNT on NLRP3 inflammasome-mediated IL-1β secretion in human THP-1 macrophages.

Methods and results

IFNT dose-dependently inhibited IL-1β secretion induced by nano-silica, a well-known activato

SUBMITTER: Hara K 

PROVIDER: S-EPMC4259327 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature