Obstructive sleep apnea is associated with future subclinical carotid artery disease: thirteen-year follow-up from the Wisconsin sleep cohort.

ABSTRACT:

Objective

To determine the longitudinal associations between obstructive sleep apnea, carotid artery intima-media thickness (IMT), and plaque.

Approach and results

This is a population-based, prospective cohort study conducted from July, 1989, to November, 2012, on 790 randomly selected Wisconsin residents who completed a mean of 3.5 (range, 1-6) polysomnograms during the study period. Obstructive sleep apnea was characterized by the apnea-hypopnea index (AHI, events/h). Common carotid artery IMT and plaque were assessed by B-mode ultrasound. The mean (SD) time from the first polysomnograms to carotid ultrasound was 13.5 (3.6) years. Multivariable regression models were created to estimate the independent associations of baseline and cumulative obstructive sleep apnea exposu

SUBMITTER: Gunnarsson SI 

PROVIDER: S-EPMC4259877 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature