Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality.

ABSTRACT:

Background

Micronutrients may influence the development or progression of liver cancer and liver disease. We evaluated the association of serum α-tocopherol, β-carotene, and retinol with incident liver cancer and chronic liver disease (CLD) mortality in a prospective cohort of middle-aged Finnish male smokers.

Methods

Baseline and 3-year follow-up serum were available from 29,046 and 22,805 men, respectively. After 24 years of follow-up, 208 men were diagnosed with liver cancer and 237 died from CLD. Hazards ratios and 95% confidence intervals were calculated for highest vs lowest quartiles from multivariate proportional hazards models.

Results

Higher β-carotene and retinol levels were associated with less liver cancer (β-carotene: 0.35, 0.22-0.55, P-trend <0.0001; re

SUBMITTER: Lai GY 

PROVIDER: S-EPMC4260018 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature