Relationship between aspirin use after diagnosis of colorectal cancer and patient survival: a meta-analysis of observational studies.

ABSTRACT:

Background

Epidemiological evidence suggests that use of aspirin after the diagnosis of colorectal cancer can lengthen survival. However, the supporting data vary between studies, and this hypothesis remains controversial. We conducted a meta-analysis to provide a quantitative assessment of the association between use of aspirin after diagnosis of colorectal cancer and patient survival.

Methods

We searched the Medline and Embase databases up to April 2014 to identify studies related to aspirin use after diagnosis and all-cause mortality or colorectal cancer-specific mortality. Summary effect estimates with 95% confidence intervals (CIs) were derived using a fixed or random effects model, depending on the heterogeneity between the included studies.

Results

Seven epidem

SUBMITTER: Ye XF 

PROVIDER: S-EPMC4260025 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature