Risk of acute liver injury associated with the use of moxifloxacin and other oral antimicrobials: a retrospective, population-based cohort study.

ABSTRACT:

Study objective

To estimate the incidence and relative risk of a hospitalization or emergency visit for noninfectious liver injury in users of eight oral antimicrobials-amoxicillin, amoxicillin-clavulanic acid, clarithromycin, cefuroxime, doxycycline, levofloxacin, moxifloxacin, telithromycin-compared with nonusers of these antimicrobials.

Design

Retrospective, observational cohort study with a nested case-control analysis.

Data source

HealthCore Integrated Research Database.

Patients

Adults with continuous health plan enrollment for at least 6 months before study entry who had a new dispensing of a study antimicrobial between July 1, 2001, and March 31, 2009. Cases had diagnoses indicating noninfectious liver injury during follow-up. To control for potentially

SUBMITTER: Kaye JA 

PROVIDER: S-EPMC4260122 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature