C677T gene polymorphism of MTHFR and metabolic syndrome: response to dietary intervention.

ABSTRACT:

Background

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were found associated with body mass index (BMI)-defined obesity and lean mass. The aim of our study was to examine the role of the C677T MTHFR gene polymorphism in the response to diet in the management of metabolic syndrome. We investigated the body composition and metabolic factor changes after an hysocaloric balanced diet (HBD), in Italian obese women affected by metabolic syndrome (MS).

Methods

Forty four obese women affected by MS were eligible for the study. A HBD for 12 weeks was assigned. Study participation included a complete screening for dietary habits, anthropometry, body composition, blood biochemical markers and C677T MTHFR polymorphism genotyping. The study has been registrated by Clin

SUBMITTER: Di Renzo L 

PROVIDER: S-EPMC4260200 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature