Tolcapone suppresses ethanol intake in alcohol-preferring rats performing a novel cued access protocol.

ABSTRACT:

Background

Dopamine (DA) has been shown to play a central role in regulating motivated behavior and encoding reward. Chronic drug abuse elicits a state of hypodopaminergia in the mesocorticolimbic (MCL) system in both humans and preclinical rodent models of addiction, including those modeling alcohol use disorders (AUD).

Methods

Working under the hypothesis that reductions in the bioavailability of DA play an integral role in the expression of the excessive drinking phenotype, the catechol-O-methyltransferase (COMT) inhibitor tolcapone was used as a means to amplify cortical DA concentration and drinking behaviors were then assessed. Sucrose and ethanol (EtOH) consumption were measured in P and Wistar rats in both a free choice drinking protocol and a novel cued access proto

SUBMITTER: McCane AM 

PROVIDER: S-EPMC4260468 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature