Unknown

Dataset Information

0

Nucleotide sequence of conjugative prophage ?1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for e?ux resistance to macrolides in Streptococcus pyogenes.

ABSTRACT: Genetic element ?1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide e?ux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that ?1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. ?1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family.

SUBMITTER: Iannelli F 

PROVIDER: S-EPMC4260502 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes.

Iannelli Francesco F   Santagati Maria M   Santoro Francesco F   Oggioni Marco R MR   Stefani Stefania S   Pozzi Gianni G  

Frontiers in microbiology 20141209

Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylati  ...[more]

Similar Datasets

Unknown ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes.
| S-EPMC4914681 | biostudies-literature
Unknown Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes.
| S-EPMC4187955 | biostudies-literature
Unknown Genetic resistance elements carrying mef subclasses other than mef(A) in Streptococcus pyogenes.
| S-EPMC3122394 | biostudies-literature
Unknown Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes.
| S-EPMC2798480 | biostudies-literature
Unknown Transduction of the Streptococcus pyogenes bacteriophage ?m46.1, carrying resistance genes mef(A) and tet(O), to other Streptococcus species.
| S-EPMC4288039 | biostudies-literature
Unknown CRISPR inhibition of prophage acquisition in Streptococcus pyogenes.
| S-EPMC3089615 | biostudies-literature
Unknown Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)-msr(D) macrolide efflux system in Streptococcus pneumoniae.
| S-EPMC8620141 | biostudies-literature
Unknown Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.
| S-EPMC7538557 | biostudies-literature
Unknown The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.
| S-EPMC3258162 | biostudies-literature
Unknown Presence of a Prophage Determines Temperature-Dependent Capsule Production in Streptococcus pyogenes.
| S-EPMC5083913 | biostudies-literature