Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential.

ABSTRACT: Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation-based feedback loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding the changes in protein abundance that mediate circadian regulation of physiology and metabolism: Understanding circadian control of gene expression is key to understanding eukaryotic, including fungal, physiology. Indeed, the isolation of clock-controlled genes (ccgs) was pioneered in Neurospora where circadian output begins with binding of the core circadian transcription factor WCC to a subset of ccg promoters, including those of many tra

SUBMITTER: Hurley JM 

PROVIDER: S-EPMC4260557 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature