Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.

ABSTRACT: A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.

SUBMITTER: Kwon KH 

PROVIDER: S-EPMC4260634 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature