Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

ABSTRACT: Several recent studies describe the influence of the gut microbiota on host brain and behavior. However, the mechanisms responsible for microbiota-nervous system interactions are largely unknown. Using a combination of genetics, biochemistry, and crystallography, we identify and characterize two phylogenetically distinct enzymes found in the human microbiome that decarboxylate tryptophan to form the β-arylamine neurotransmitter tryptamine. Although this enzymatic activity is exceedingly rare among bacteria more broadly, analysis of the Human Microbiome Project data demonstrate that at least 10% of the human population harbors at least one bacterium encoding a tryptophan decarboxylase in their gut community. Our results uncover a previously unrecognized enzymatic activity that can give rise

SUBMITTER: Williams BB 

PROVIDER: S-EPMC4260654 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature