Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network.

ABSTRACT:

Background

Lineage segregation from multipotent epithelia is a central theme in development and in adult stem cell plasticity. Previously, we demonstrated that striated and smooth muscle cells share a common progenitor within their epithelium of origin, the lateral domain of the somite-derived dermomyotome. However, what controls the segregation of these muscle subtypes remains unknown. We use this in vivo bifurcation of fates as an experimental model to uncover the underlying mechanisms of lineage diversification from bipotent progenitors.

Results

Using the strength of spatio-temporally controlled gene missexpression in avian embryos, we report that Notch harbors distinct pro-smooth muscle activities depending on the duration of the signal; short periods prevent striated mu

SUBMITTER: Applebaum M 

PROVIDER: S-EPMC4260679 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature