The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination.

ABSTRACT: The microbial colonization of the intestine during the first months of life constitutes the most important process for the microbiota-induced host-homeostasis. Alterations in this process may entail a high-risk for disease in later life. However, the potential factors affecting this process in the infant are not well known. Moreover, the potential impact of orally administered vaccines upon the establishing microbiome remains unknown. Here we assessed the intestinal microbiome establishment process and evaluated the impact of rotavirus vaccination upon this process. Metagenomic, PCR-DGGE and faecal short chain fatty acids analyses were performed on faecal samples obtained from three infants before and after the administration of each dose of vaccine. We found a high inter-individual variab

SUBMITTER: Ang L 

PROVIDER: S-EPMC4261165 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature