Early exposure of infants to natural rotavirus infection: a review of studies with human rotavirus vaccine RIX4414.

ABSTRACT:

Background

Rotaviruses are the leading cause of severe acute gastroenteritis in children aged <5 years worldwide. A live attenuated human rotavirus vaccine, RIX4414 has been developed to reduce the global disease burden associated with rotavirus gastroenteritis. Serum anti-rotavirus immunoglobulin A (IgA) antibody measured in unvaccinated infants during clinical trials of RIX4414 reflects natural rotavirus exposure, and may inform the optimal timing for rotavirus vaccination.

Methods

We reviewed phase II and III randomized, placebo-controlled clinical trials conducted by GlaxoSmithKline Vaccines, Wavre, Belgium between 2000 and 2008 which used the commercial formulation of RIX4414 lyophilized vaccine. We included trials for which demographic data and pre-dose-1 and post-last

SUBMITTER: Cunliffe N 

PROVIDER: S-EPMC4261882 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature