Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.

ABSTRACT: The role of extra-synaptic receptors in the regulation of excitation and inhibition in the brain has attracted increasing attention. Because activity in the extra-synaptic receptors plays a role in regulating the level of excitation and inhibition in the brain, they may be important in determining the level of consciousness. This paper reviews briefly the literature on extra-synaptic GABA and NMDA receptors and their affinity to anesthetic drugs. We propose a neural population model that illustrates how the effect of the anesthetic drug propofol on GABAergic extra-synaptic receptors results in changes in neural population activity and the electroencephalogram (EEG). Our results show that increased tonic inhibition in inhibitory cortical neurons cause a dramatic increase in the power of bot

SUBMITTER: Hashemi M 

PROVIDER: S-EPMC4261904 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature