Prognostic significance of the morning blood pressure surge in clinical practice: a systematic review.

ABSTRACT:

Background

An exaggerated morning blood pressure surge (MBPS) may be associated with stroke and other cardiovascular events, but the threshold at which an MBPS becomes pathological is unclear. This study aimed to systematically review the existing literature and establish the most appropriate definition of pathological MBPS.

Methods

A MEDLINE search strategy was adapted for a range of literature databases to identify all prospective studies relating an exaggerated MBPS to cardiovascular endpoints. Hazard ratios (HRs) were extracted and synthesized using random-effects meta-analysis.

Results

The search strategy identified 2,964 unique articles, of which 17 were eligible for the study. Seven different definitions of MBPS were identified; the most common was a prewaking

SUBMITTER: Sheppard JP 

PROVIDER: S-EPMC4261916 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature