MAE-FMD: multi-agent evolutionary method for functional module detection in protein-protein interaction networks.

ABSTRACT:

Background

Studies of functional modules in a Protein-Protein Interaction (PPI) network contribute greatly to the understanding of biological mechanisms. With the development of computing science, computational approaches have played an important role in detecting functional modules.

Results

We present a new approach using multi-agent evolution for detection of functional modules in PPI networks. The proposed approach consists of two stages: the solution construction for agents in a population and the evolutionary process of computational agents in a lattice environment, where each agent corresponds to a candidate solution to the detection problem of functional modules in a PPI network. First, the approach utilizes a connection-based encoding scheme to model an agent, and em

SUBMITTER: Ji JZ 

PROVIDER: S-EPMC4262229 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature