Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.

ABSTRACT: Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.

SUBMITTER: Moga KA 

PROVIDER: S-EPMC4262250 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature