Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology.

ABSTRACT: We describe a sequence of methods to produce a partial differential equation model of the electrical activation of the ventricles. In our framework, we incorporate the anatomy and cardiac microstructure obtained from magnetic resonance imaging and diffusion tensor imaging of a New Zealand White rabbit, the Purkinje structure and the Purkinje-muscle junctions, and an electrophysiologically accurate model of the ventricular myocytes and tissue, which includes transmural and apex-to-base gradients of action potential characteristics. We solve the electrophysiology governing equations using the finite element method and compute both a 6-lead precordial electrocardiogram (ECG) and the activation wavefronts over time. We are particularly concerned with the validation of the various methods used

SUBMITTER: Krishnamoorthi S 

PROVIDER: S-EPMC4262432 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature