Association between endometriosis and the interleukin 1A (IL1A) locus.

ABSTRACT:

Study question

Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk?

Summary answer

We found evidence for strong association between IL1A SNPs and endometriosis risk.

What is known already

Genetic factors contribute substantially to the complex aetiology of endometriosis and the disease has an estimated heritability of ∼51%. We, and others, have conducted genome-wide association (GWA) studies for endometriosis, which identified a total of nine independent risk loci. Recently, two small Japanese studies reported eight SNPs (rs6542095, rs11677416, rs3783550, rs3783525, rs3783553, rs2856836, rs1304037 and rs17561) at the IL1A gene locus as suggestively associated with endometriosis risk. There is also evide

SUBMITTER: Sapkota Y 

PROVIDER: S-EPMC4262465 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature