Integrative modeling of multi-platform genomic data under the framework of mediation analysis.

ABSTRACT: Given the availability of genomic data, there have been emerging interests in integrating multi-platform data. Here, we propose to model genetics (single nucleotide polymorphism (SNP)), epigenetics (DNA methylation), and gene expression data as a biological process to delineate phenotypic traits under the framework of causal mediation modeling. We propose a regression model for the joint effect of SNPs, methylation, gene expression, and their nonlinear interactions on the outcome and develop a variance component score test for any arbitrary set of regression coefficients. The test statistic under the null follows a mixture of chi-square distributions, which can be approximated using a characteristic function inversion method or a perturbation procedure. We construct tests for candidate mod

SUBMITTER: Huang YT 

PROVIDER: S-EPMC4262570 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature