In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation.

ABSTRACT: The age of pubertal onset for girls has declined over past decades. Research suggests that endocrine disrupting chemicals (EDCs) may play a role but exposure at multiple stages of development has not been considered. We examined in utero and peripubertal exposure to bisphenol-A (BPA) and phthalates in relation to serum hormones and sexual maturation among females in a Mexico City birth cohort. We measured phthalate metabolite and BPA concentrations in urine collected from mothers during their third trimester (n=116) and from their female children at ages 8-13 years (n=129). Among girls, we measured concurrent serum hormone concentrations, Tanner stages for breast and pubic hair development, and collected information on menarche onset. We used linear and logistic regression to model associa

SUBMITTER: Watkins DJ 

PROVIDER: S-EPMC4262586 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature