Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study.

ABSTRACT: IMPORTANCE Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of amelanotic melanomas, selected populations, lack of centralized pathologic review, or no adjustment for stage limit the interpretation or generalization of results from prior studies.OBJECTIVE To compare melanoma-specific survival between patients with histopathologically amelanotic and those with pigmented melanoma in a large international population-based study.DESIGN, SETTING, AND PARTICIPANTS Survival analysis with a median follow-up of 7.6 years.The study population comprised 2995 patients with 3486 invasive primary melanomas centrally scored for histologic pigmentation from the Genes, Environment, and Melanoma(GEM

SUBMITTER: Thomas NE 

PROVIDER: S-EPMC4262611 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature