The reduction of serum soluble Flt-1 in patients with neovascular age-related macular degeneration.

ABSTRACT:

Purpose

To evaluate serum soluble Flt-1 (sFlt-1) in age-related macular degeneration (AMD) patients.

Design

Case-control study.

Methods

Study involved 56 non-AMD participants, 53 early AMD patients, and 97 neovascular AMD patients from Belfast in Northern Ireland. Serum samples were collected from each patient. Serum sFlt-1 was measured by human sVEGFR1/sFlt-1 ELISA kit. The results were analyzed by Excel and SPSS.

Results

Serum sFlt-1 concentration of non-AMD, early AMD, and neovascular AMD were 90.8 ± 2.9 pg/mL (± standard error of the mean), 88.2 ± 2.6 pg/mL, and 79.9 ± 2.2 pg/mL. sFlt-1 from neovascular AMD patients was significantly decreased compared to non-AMD and early AMD patients (ANOVA, P < .01). For each 10-point increase in sFlt-1, the odds for hav

SUBMITTER: Uehara H 

PROVIDER: S-EPMC4262635 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature